InnateDB Protein
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IDBP-190855.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Trpm1
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Protein Name
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transient receptor potential cation channel, subfamily M, member 1
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Synonyms
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4732499L03Rik; AI606771; Ltrpc1; melastatin; Mlsn1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000032737
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InnateDB Gene
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IDBG-190849 (Trpm1)
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Protein Structure
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Function |
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel. {ECO:0000269PubMed:19861548, ECO:0000269PubMed:19966281, ECO:0000269PubMed:9537257}.
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Subcellular Localization |
Cell membrane {ECO:0000255, ECO:0000305}; Multi-pass membrane protein {ECO:0000255, ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in the retina where it localizes on dendritic tips of ON bipolar cells. Not detected in brain, lung, liver, heart, kidney, spleen or small intestine. Also expressed at high levels in poorly metastatic variants of B16 melanoma and at much reduced levels in highly metastatic variants of B16 melanoma. {ECO:0000269PubMed:19861548, ECO:0000269PubMed:19966281, ECO:0000269PubMed:9537257}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1330305
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q2TV84
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PhosphoSite |
PhosphoSite-Q2TV84
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TrEMBL |
D3YYQ2
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UniProt Splice Variant |
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Entrez Gene |
17364
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UniGene |
Mm.404453
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RefSeq |
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MGI ID |
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MGI Symbol |
Trpm1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC127565
AC139849
AF047714
AJ867481
AK148094
AK148268
AK148275
AK149290
AK164395
AY180104
BC082560
BC085168
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GenPept |
AAC13683
AAH82560
AAH85168
AAO43093
BAE28340
BAE28448
BAE28453
BAE28794
BAE37771
CAI30140
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