InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rassf5

Summary

InnateDB Protein

IDBP-190931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rassf5

Protein Name

Ras association (RalGDS/AF-6) domain family member 5

Synonyms

1300019G20Rik; AU042887; Maxp1; Nore1; Nore1A; Nore1B; Rapl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027688

InnateDB Gene

IDBG-190929 (Rassf5)

Protein Structure

UniProt Annotation

Function

Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000250, ECO:0000269PubMed:11864565}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0031398	positive regulation of protein ubiquitination
GO:0035556	intracellular signal transduction
GO:1900180	regulation of protein localization to nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule

Protein Structure and Domains

PDB ID

MGI:1926375

InterPro

IPR000159 Ras-association
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR011524 SARAH domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00130

PRINTS

PIRSF

SMART

SM00314
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5EBH1