Version 5.4
Mus musculus Gene: Rassf5
Summary
InnateDB Gene IDBG-190929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rassf5
Gene Name Ras association (RalGDS/AF-6) domain family member 5
Synonyms 1300019G20Rik; AU042887; Maxp1; Nore1; Nore1A; Nore1B; Rapl
Species Mus musculus
Ensembl Gene ENSMUSG00000026430
Encoded Proteins
IDBP-190931
Ras association (RalGDS/AF-6) domain family member 5
IDBP-190933
Ras association (RalGDS/AF-6) domain family member 5
IDBP-256009
Ras association (RalGDS/AF-6) domain family member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:131176410-131245258
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000027688 ENSMUSP00000027688
ENSMUST00000068564 ENSMUSP00000067011
ENSMUST00000112442 ENSMUSP00000108061
ENSMUST00000124796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0031398 positive regulation of protein ubiquitination
GO:0035556 intracellular signal transduction
GO:1900180 regulation of protein localization to nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000010427
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04670
Leukocyte transendothelial migration pathway
mmu05223
Non-small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_018750 XM_006529756
OMIM
CCDS CCDS15268
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca