InnateDB Protein
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IDBP-190933.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rassf5
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Protein Name
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Ras association (RalGDS/AF-6) domain family member 5
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Synonyms
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1300019G20Rik; AU042887; Maxp1; Nore1; Nore1A; Nore1B; Rapl;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000067011
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InnateDB Gene
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IDBG-190929 (Rassf5)
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Protein Structure
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Function |
Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000250, ECO:0000269PubMed:11864565}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1926375
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InterPro |
IPR000159
Ras-association
IPR011524
SARAH domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF00788
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PRINTS |
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PIRSF |
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SMART |
SM00314
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TIGRFAMs |
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Modification |
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SwissProt |
Q5EBH1
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PhosphoSite |
PhosphoSite-Q5EBH1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54354
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UniGene |
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RefSeq |
XP_006529819
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MGI ID |
3DDC
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MGI Symbol |
Rassf5
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF053959
AK088751
AK131147
AK155534
AK155869
AY261333
BC089605
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GenPept |
AAC08580
AAH89605
AAP83361
BAC40546
BAD21397
BAE33312
BAE33472
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