Version 5.4
Mus musculus Protein: Wrap53
Summary
InnateDB Protein IDBP-190974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wrap53
Protein Name WD repeat containing, antisense to TP53
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047825
InnateDB Gene IDBG-190972 (Wrap53)
Protein Structure
UniProt Annotation
Function Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post- transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, Cajal body. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0032203 telomere formation via telomerase
GO:0051973 positive regulation of telomerase activity
Cellular Component
GO:0005634 nucleus
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
Protein Structure and Domains
PDB ID MGI:2384933
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VC51
PhosphoSite PhosphoSite-Q8VC51
TrEMBL I7HJ86
UniProt Splice Variant
Entrez Gene 216853
UniGene Mm.404762
RefSeq NP_659073
MGI ID
MGI Symbol Wrap53
OMIM
CCDS CCDS24897
HPRD
IMGT
EMBL AL731687 BC021790 BC069868
GenPept AAH21790 AAH69868 CAI52013 CAI52014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca