InnateDB Protein
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IDBP-190977.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zic1
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Protein Name
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zinc finger protein of the cerebellum 1
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Synonyms
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ZIC; ZNF201;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034927
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InnateDB Gene
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IDBG-190975 (Zic1)
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Protein Structure
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Function |
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3'. {ECO:0000269PubMed:11053430, ECO:0000269PubMed:11238441, ECO:0000269PubMed:11944941, ECO:0000269PubMed:15207726, ECO:0000269PubMed:19303920, ECO:0000269PubMed:20354137, ECO:0000269PubMed:7931345}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.
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Disease Associations |
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Tissue Specificity |
Expressed in osteoblasts (at protein level). Expressed in the CNS. A high level expression is seen in the cerebellum, while a low level expression is seen in the olfactory bulb, diencephalon, and brainstem. Expressed in lumbar spine and iliac crest. {ECO:0000269PubMed:19303920, ECO:0000269PubMed:20354137, ECO:0000269PubMed:7931345}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106683
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
P46684
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PhosphoSite |
PhosphoSite-
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TrEMBL |
G3UYA5
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UniProt Splice Variant |
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Entrez Gene |
22771
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UniGene |
Mm.477226
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RefSeq |
XP_006511124
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MGI ID |
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MGI Symbol |
Zic1
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OMIM |
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CCDS |
CCDS23403
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HPRD |
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IMGT |
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EMBL |
AC116582
AK136977
BC050889
BC060247
BC063247
CH466560
D32167
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GenPept |
AAH50889
AAH60247
AAH63247
BAA06878
BAE23194
EDL20910
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