InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pacsin3

Summary

InnateDB Protein

IDBP-190997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pacsin3

Protein Name

protein kinase C and casein kinase substrate in neurons 3

Synonyms

4921507A02Rik; 6330413E15Rik; AW413130;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028694

InnateDB Gene

IDBG-190993 (Pacsin3)

Protein Structure

UniProt Annotation

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. {ECO:0000269PubMed:11082044, ECO:0000269PubMed:16627472, ECO:0000269PubMed:17320047, ECO:0000269PubMed:18174177}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11082044}. Cell membrane {ECO:0000269PubMed:11082044}; Peripheral membrane protein {ECO:0000269PubMed:11082044}; Cytoplasmic side {ECO:0000269PubMed:11082044}. Note=Detected at the inner aspect of the plasma membrane in myotubes.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle, heart and lung; also detected in brain, kidney and uterus (at protein level). {ECO:0000269PubMed:11082044}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008289	lipid binding
GO:0019855	calcium channel inhibitor activity

Biological Process

GO:0006897	endocytosis
GO:0045806	negative regulation of endocytosis
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051926	negative regulation of calcium ion transport
GO:0097320	membrane tubulation