InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arfgap2

Summary

InnateDB Protein

IDBP-191076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arfgap2

Protein Name

ADP-ribosylation factor GTPase activating protein 2

Synonyms

2310032E02Rik; Zfp289;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078920

InnateDB Gene

IDBG-191074 (Arfgap2)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi- derived membranes to allow fusion with target membranes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in liver, heart and kidney. Low expression in skeletal muscle and spleen. {ECO:0000269PubMed:11278321}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity