Version 5.4
Mus musculus Gene: Arfgap2
Summary
InnateDB Gene IDBG-191074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arfgap2
Gene Name ADP-ribosylation factor GTPase activating protein 2
Synonyms 2310032E02Rik; Zfp289
Species Mus musculus
Ensembl Gene ENSMUSG00000027255
Encoded Proteins
IDBP-191076
ADP-ribosylation factor GTPase activating protein 2
IDBP-191078
ADP-ribosylation factor GTPase activating protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91264974-91276931
Strand Forward strand
Band E1
Transcripts
ENSMUST00000080008 ENSMUSP00000078920
ENSMUST00000028691 ENSMUSP00000028691
ENSMUST00000150701
ENSMUST00000150753
ENSMUST00000128296
ENSMUST00000146228
ENSMUST00000127895
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149182
View Gene Order
ENSBTAG00000009574
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q99K28
TrEMBL Q3UR67
UniProt Splice Variant
Entrez Gene 77038
UniGene Mm.43636
RefSeq NM_001166024 NM_023854
OMIM
CCDS CCDS16430 CCDS50639
HPRD
IMGT
MGI ID MGI:1924288
MGI Symbol Arfgap2
EMBL AF229439 AK009565 AK141749 AK149837 AK168489 AK169144 AL732478 BC005495
GenPept AAF91258 AAH05495 BAB26362 BAE24821 BAE29114 BAE40376 BAE40923 CAM24080 CAM24081
RNA Seq Atlas 77038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca