Version 5.4
Mus musculus Protein: St6gal2
Summary
InnateDB Protein IDBP-191092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St6gal2
Protein Name beta galactoside alpha 2,6 sialyltransferase 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025000
InnateDB Gene IDBG-191090 (St6gal2)
Protein Structure
UniProt Annotation
Function Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Mainly expressed in brain and embryo. Very low expression is also detected in spleen, oviduct, lung and skeletal muscle. {ECO:0000269PubMed:12966079}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006054 N-acetylneuraminate metabolic process
GO:0006486 protein glycosylation
GO:0009311 oligosaccharide metabolic process
GO:0097503 sialylation
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID MGI:2445190
InterPro IPR001675 Glycosyl transferase, family 29
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
PFAM PF00777
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q76K27
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 240119
UniGene Mm.311687
RefSeq XP_006524329
MGI ID
MGI Symbol St6gal2
OMIM
CCDS
HPRD
IMGT
EMBL AB095093 AK082566 AK129462 BC125586 CT009635
GenPept AAI25587 BAC38534 BAC87752 BAC98272 CAP19181 CAP19182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca