InnateDB Protein
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IDBP-191094.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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St6gal2
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Protein Name
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beta galactoside alpha 2,6 sialyltransferase 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000084091
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InnateDB Gene
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IDBG-191090 (St6gal2)
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Protein Structure
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Function |
Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Mainly expressed in brain and embryo. Very low expression is also detected in spleen, oviduct, lung and skeletal muscle. {ECO:0000269PubMed:12966079}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003824
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catalytic activity
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GO:0003835
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beta-galactoside alpha-2,6-sialyltransferase activity
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GO:0008373
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sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2445190
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR011330
Glycoside hydrolase/deacetylase, beta/alpha-barrel
IPR012163
Sialyltransferase
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PFAM |
PF00777
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PRINTS |
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PIRSF |
PIRSF005557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q76K27
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B2RQY9
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UniProt Splice Variant |
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Entrez Gene |
240119
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UniGene |
Mm.311687
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RefSeq |
NP_766417
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MGI ID |
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MGI Symbol |
St6gal2
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OMIM |
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CCDS |
CCDS28886
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HPRD |
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IMGT |
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EMBL |
AB095093
AK082566
AK129462
BC125586
BC138142
CT009635
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GenPept |
AAI25587
AAI38143
BAC38534
BAC87752
BAC98272
CAP19181
CAP19182
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