InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfip11

Summary

InnateDB Protein

IDBP-191100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfip11

Protein Name

tuftelin interacting protein 11

Synonyms

2810002G02Rik; AF097181; AW046167; Srr1; TIP33; Tip39;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031288

InnateDB Gene

IDBG-191098 (Tfip11)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269PubMed:15868102, ECO:0000269PubMed:19857462}.

Subcellular Localization

Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.

Disease Associations

Tissue Specificity

Widely expressed. In tooth it is expressed in ameloblasts and odontoblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0000390	spliceosomal complex disassembly
GO:0006355	regulation of transcription, DNA-templated
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0031214	biomineral tissue development

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0071008	U2-type post-mRNA release spliceosomal complex
GO:0071013	catalytic step 2 spliceosome