InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apba2

Summary

InnateDB Protein

IDBP-191189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apba2

Protein Name

amyloid beta (A4) precursor protein-binding, family A, member 2

Synonyms

mXllL; X11-like; X11L; XllL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032732

InnateDB Gene

IDBG-191187 (Apba2)

Protein Structure

UniProt Annotation

Function

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

Subcellular Localization

Disease Associations

Tissue Specificity

Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0010468	regulation of gene expression
GO:0015031	protein transport
GO:0035264	multicellular organism growth