InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apba2

Summary

InnateDB Gene

IDBG-191187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apba2

Gene Name

amyloid beta (A4) precursor protein-binding, family A, member 2

Synonyms

mXllL; X11-like; X11L; XllL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030519

Encoded Proteins

IDBP-191189

amyloid beta (A4) precursor protein-binding, family A, member 2

IDBP-191191

amyloid beta (A4) precursor protein-binding, family A, member 2

IDBP-266517

amyloid beta (A4) precursor protein-binding, family A, member 2

IDBP-540454

amyloid beta (A4) precursor protein-binding, family A, member 2

IDBP-540483

amyloid beta (A4) precursor protein-binding, family A, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000034053:
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer\'s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer\'s disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:64501706-64753870

Strand

Forward strand

Band

Transcripts

ENSMUST00000032732	ENSMUSP00000032732
ENSMUST00000096173	ENSMUSP00000093887
ENSMUST00000107507	ENSMUSP00000103131
ENSMUST00000138829	ENSMUSP00000122857
ENSMUST00000137732	ENSMUSP00000114194

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0010468	regulation of gene expression
GO:0015031	protein transport
GO:0035264	multicellular organism growth

Cellular Component

GO:0005886

plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000034053

View Gene Order

ENSBTAG00000020413

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.4657

RefSeq

NM_001291166 NM_001291167 NM_007461 XM_006540572 XM_006540573 XM_006540574 XM_006540575 XM_006540576

OMIM

CCDS

CCDS21335

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas