InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hp

Summary

InnateDB Protein

IDBP-191237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

haptoglobin

Synonyms

HP-1; preHP2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074436

InnateDB Gene

IDBG-191235 (Hp)

Protein Structure

UniProt Annotation

Function

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). {ECO:0000250}.Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0016209	antioxidant activity
GO:0030492	hemoglobin binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001889	liver development
GO:0002376	immune system process
GO:0002526	acute inflammatory response
GO:0006508	proteolysis
GO:0006953	acute-phase response
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0009408	response to heat
GO:0009725	response to hormone
GO:0010033	response to organic substance
GO:0010165	response to X-ray
GO:0010288	response to lead ion
GO:0014070	response to organic cyclic compound
GO:0031100	organ regeneration
GO:0032026	response to magnesium ion
GO:0032496	response to lipopolysaccharide
GO:0033590	response to cobalamin
GO:0033591	response to L-ascorbic acid
GO:0042493	response to drug
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0051384	response to glucocorticoid
GO:0051602	response to electrical stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

MGI:96211

InterPro

IPR000436 Sushi/SCR/CCP
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR008292 Haptoglobin
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00084
PF00089

PRINTS

PR00722

PIRSF

PIRSF001137

SMART

SM00032
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References