Version 5.4
Mus musculus Gene: Hp
Summary
InnateDB Gene IDBG-191235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hp
Gene Name haptoglobin
Synonyms HP-1; preHP2
Species Mus musculus
Ensembl Gene ENSMUSG00000031722
Encoded Proteins
IDBP-191237
haptoglobin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22156194
Haptoglobin activates innate immunity to enhance acute transplant rejection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000261701:
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:109575130-109579172
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000074898 ENSMUSP00000074436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0016209 antioxidant activity
GO:0030492 hemoglobin binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001889 liver development
GO:0002376 immune system process
GO:0002526 acute inflammatory response
GO:0006508 proteolysis
GO:0006953 acute-phase response
GO:0007283 spermatogenesis
GO:0008152 metabolic process
GO:0009408 response to heat
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010165 response to X-ray
GO:0010288 response to lead ion
GO:0014070 response to organic cyclic compound
GO:0031100 organ regeneration
GO:0032026 response to magnesium ion
GO:0032496 response to lipopolysaccharide
GO:0033590 response to cobalamin
GO:0033591 response to L-ascorbic acid
GO:0042493 response to drug
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0051384 response to glucocorticoid
GO:0051602 response to electrical stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000261701
View Gene Order
Pathways
NETPATH
REACTOME
REACT_196575
Scavenging of heme from plasma pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
Cross-References
SwissProt Q61646
TrEMBL Q3UBS3
UniProt Splice Variant
Entrez Gene 15439
UniGene
RefSeq NM_017370
OMIM
CCDS CCDS40470
HPRD
IMGT
MGI ID MGI:96211
MGI Symbol Hp
EMBL AK150430 AK150830 AK152295 AK152698 AK159676 BC138872 CH466525 M96827
GenPept AAA37779 AAI38873 BAE29553 BAE29891 BAE31104 BAE31428 BAE35279 EDL11423
RNA Seq Atlas 15439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca