Version 5.4
Mus musculus Protein: Ckap5
Summary
InnateDB Protein IDBP-191257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ckap5
Protein Name cytoskeleton associated protein 5
Synonyms 3110043H24Rik; 4930432B04Rik; D730027C18Rik; mKIAA0097; T25636;
Species Mus musculus
Ensembl Protein ENSMUSP00000046263
InnateDB Gene IDBG-191253 (Ckap5)
Protein Structure
UniProt Annotation
Function Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Detected on centrosomes during interphase. Detected on spindle poles and microtubules during mitosis (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0050658 RNA transport
Cellular Component
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0015630 microtubule cytoskeleton
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1923036
InterPro IPR000357 HEAT
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2
IPR024395 CLASP N-terminal domain
IPR027434 Homing endonuclease
PFAM PF02985
PF12348
PF14528
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AGT5
PhosphoSite PhosphoSite-A2AGT5
TrEMBL
UniProt Splice Variant
Entrez Gene 75786
UniGene Mm.168478
RefSeq NP_083713
MGI ID
MGI Symbol Ckap5
OMIM
CCDS CCDS16433
HPRD
IMGT
EMBL AK015282 AK149854 AK165862 AL691489 BC017140 BC089032 BC096422 BC138334
GenPept AAH17140 AAH89032 AAH96422 AAI38335 BAB29779 BAE29125 BAE38422

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca