InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ebi3

Summary

InnateDB Protein

IDBP-191288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ebi3

Protein Name

Epstein-Barr virus induced gene 3

Synonyms

EBI-3; IL-27;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003274

InnateDB Gene

IDBG-191286 (Ebi3)

Protein Structure

UniProt Annotation

Function

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0045523	interleukin-27 receptor binding