InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tjp1

Summary

InnateDB Protein

IDBP-191304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tjp1

Protein Name

tight junction protein 1

Synonyms

ZO1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099652

InnateDB Gene

IDBG-191302 (Tjp1)

Protein Structure

UniProt Annotation

Function

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, gap junction {ECO:0000269PubMed:20093627}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000269PubMed:20093627}. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding

Biological Process

GO:0001825	blastocyst formation
GO:0007605	sensory perception of sound
GO:0032496	response to lipopolysaccharide
GO:0042493	response to drug
GO:0043116	negative regulation of vascular permeability
GO:0045471	response to ethanol
GO:0071000	response to magnetism
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005921	gap junction
GO:0005923	tight junction
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030054	cell junction
GO:0031674	I band
GO:0043296	apical junction complex
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus

Protein Structure and Domains

PDB ID

MGI:98759

InterPro

IPR000906 ZU5
IPR001452 SH3 domain
IPR001478 PDZ domain
IPR005417 Zona occludens protein
IPR005418 Zona occludens protein ZO-1
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM