InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tjp1

Summary

InnateDB Protein

IDBP-191306.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Tjp1

Protein Name

tight junction protein 1

Synonyms

ZO1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032729

InnateDB Gene

IDBG-191302 (Tjp1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0001825	blastocyst formation
GO:0007605	sensory perception of sound

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005923	tight junction
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030054	cell junction
GO:0043296	apical junction complex
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus

Protein Structure and Domains

PDB ID

MGI:98759

InterPro

IPR000906 ZU5
IPR001452 SH3 domain
IPR001478 PDZ domain
IPR005417 Zona occludens protein
IPR005418 Zona occludens protein ZO-1
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM