InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pkd1l3

Summary

InnateDB Protein

IDBP-191344.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pkd1l3

Protein Name

polycystic kidney disease 1 like 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051512

InnateDB Gene

IDBG-191342 (Pkd1l3)

Protein Structure

UniProt Annotation

Function

Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO:0000269PubMed:16805797, ECO:0000269PubMed:16891422, ECO:0000269PubMed:16929298, ECO:0000269PubMed:21098668, ECO:0000269PubMed:21625513}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16891422, ECO:0000269PubMed:21185261}; Multi-pass membrane protein {ECO:0000269PubMed:16891422, ECO:0000269PubMed:21185261}. Note=Interaction with PKD2L1 is required for localization to the cell membrane.

Disease Associations

Tissue Specificity

Expressed in a subset of taste receptor cells distinct from those involved in bitter, sweet and umami taste. Expressed in circumvallate and foliate taste buds, but not in surrounding non-gustatory lingual epithelium cells. Expressed in testis. {ECO:0000269PubMed:16805797, ECO:0000269PubMed:16891422, ECO:0000269PubMed:16929298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008324	cation transmembrane transporter activity
GO:0030246	carbohydrate binding
GO:0033040	sour taste receptor activity

Biological Process

GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007218	neuropeptide signaling pathway
GO:0050982	detection of mechanical stimulus
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071468	cellular response to acidity

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2664670

InterPro

IPR000203 GPS motif
IPR000434 Polycystic kidney disease type 1 protein
IPR001024 PLAT/LH2 domain
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR016187 C-type lectin fold

PFAM

PF01825
PF01477
PF00520
PF08016

PRINTS

PR00500
PR01433

PIRSF

SMART

SM00303
SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt