InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ist1

Summary

InnateDB Protein

IDBP-191369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ist1

Protein Name

RIKEN cDNA 2400003C14 gene

Synonyms

2400003C14Rik; AW536298; mKIAA0174;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034164

InnateDB Gene

IDBG-191367 (Ist1)

Protein Structure

UniProt Annotation

Function

Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle {ECO:0000250}. Note=Localizes to the midbody of dividing cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0090541	MIT domain binding

Biological Process

GO:0000910	cytokinesis
GO:0008104	protein localization
GO:0009838	abscission
GO:0019076	viral release from host cell
GO:0045184	establishment of protein localization
GO:0045862	positive regulation of proteolysis
GO:0046745	viral capsid secondary envelopment
GO:0048672	positive regulation of collateral sprouting
GO:0051301	cell division

Cellular Component

GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030496	midbody
GO:0070062	extracellular vesicular exosome
GO:0090543	Flemming body