InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc26a9

Summary

InnateDB Protein

IDBP-191412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc26a9

Protein Name

solute carrier family 26, member 9

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036916

InnateDB Gene

IDBG-191410 (Slc26a9)

Protein Structure

UniProt Annotation

Function

DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate. {ECO:0000269PubMed:15800055, ECO:0000269PubMed:17120765}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in stomach and trachea. Abundantly expressed in the apical domain of the surface epithelial cells and the deep cells in the gastric gland. Also expressed in heart, brain, lung and liver. {ECO:0000269PubMed:15800055}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0051117	ATPase binding

Biological Process

GO:0006820	anion transport
GO:0006821	chloride transport
GO:0006885	regulation of pH
GO:0008272	sulfate transport
GO:0010628	positive regulation of gene expression
GO:0015701	bicarbonate transport
GO:0055085	transmembrane transport
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome