InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgap1

Summary

InnateDB Protein

IDBP-191462.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap1

Protein Name

Rho GTPase activating protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088105

InnateDB Gene

IDBG-191458 (Arhgap1)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0043087	regulation of GTPase activity