Version 5.4
Mus musculus Gene: Arhgap1
Summary
InnateDB Gene IDBG-191458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap1
Gene Name Rho GTPase activating protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027247
Encoded Proteins
IDBP-191462
Rho GTPase activating protein 1
IDBP-258360
Rho GTPase activating protein 1
IDBP-258362
Rho GTPase activating protein 1
IDBP-258364
Rho GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175220:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91649860-91672326
Strand Forward strand
Band E1
Transcripts
ENSMUST00000090614 ENSMUSP00000088105
ENSMUST00000111331 ENSMUSP00000106963
ENSMUST00000111330 ENSMUSP00000106962
ENSMUST00000111329 ENSMUSP00000106961
ENSMUST00000139314
ENSMUST00000154468
ENSMUST00000141012
ENSMUST00000123702
ENSMUST00000149426
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031252 cell leading edge
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175220
View Gene Order
ENSBTAG00000016501
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt Q5FWK3
TrEMBL A2AH25 Q8C5A0
UniProt Splice Variant
Entrez Gene 228359
UniGene Mm.22413
RefSeq NM_001145902 NM_146124 XM_006499244 XM_006499245 XM_006499246 XM_006499247 XM_006499248 XM_006499249 XM_006499250 XM_006499251
OMIM
CCDS CCDS16437 CCDS50641
HPRD
IMGT
MGI ID MGI:2445003
MGI Symbol Arhgap1
EMBL AK079048 AK084622 AL691489 AL714023 BC006592 BC089306
GenPept AAH06592 AAH89306 BAC37513 BAC39233 CAM14522
RNA Seq Atlas 228359

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca