InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcsk6

Summary

InnateDB Protein

IDBP-191468.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Pcsk6

Protein Name

proprotein convertase subtilisin/kexin type 6

Synonyms

C86343; Pace4; SPC4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053742

InnateDB Gene

IDBG-191466 (Pcsk6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0048406	nerve growth factor binding

Biological Process

GO:0006508	proteolysis
GO:0007354	zygotic determination of anterior/posterior axis, embryo
GO:0007368	determination of left/right symmetry
GO:0009100	glycoprotein metabolic process
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0032902	nerve growth factor production
GO:0032940	secretion by cell

Cellular Component

GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0009986	cell surface
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:102897

InterPro

IPR000209 Peptidase S8/S53 domain
IPR000742 Epidermal growth factor-like domain
IPR002884 Proprotein convertase, P
IPR006212 Furin-like repeat
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR010909 PLAC
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF00008
PF01483
PF08686

PRINTS

PR00723

PIRSF

SMART

SM00181
SM00261

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt