Version 5.4
Mus musculus Gene: Pcsk6
Summary
InnateDB Gene IDBG-191466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcsk6
Gene Name proprotein convertase subtilisin/kexin type 6
Synonyms C86343; Pace4; SPC4
Species Mus musculus
Ensembl Gene ENSMUSG00000030513
Encoded Proteins
IDBP-191468
proprotein convertase subtilisin/kexin type 6
IDBP-191470
proprotein convertase subtilisin/kexin type 6
IDBP-722459
IDBP-722495
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140479:
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:65861734-66050340
Strand Forward strand
Band C
Transcripts
ENSMUST00000055576 ENSMUSP00000053742
ENSMUST00000098391 ENSMUSP00000095992
ENSMUST00000177272
ENSMUST00000177369
ENSMUST00000176199 ENSMUSP00000135851
ENSMUST00000176209 ENSMUSP00000135033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008233 peptidase activity
GO:0048406 nerve growth factor binding
Biological Process
GO:0006508 proteolysis
GO:0007354 zygotic determination of anterior/posterior axis, embryo
GO:0007368 determination of left/right symmetry
GO:0009100 glycoprotein metabolic process
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0032902 nerve growth factor production
GO:0032940 secretion by cell
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0009986 cell surface
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140479
View Gene Order
ENSBTAG00000006675
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11062
NGF processing pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BLN2
UniProt Splice Variant
Entrez Gene 18553
UniGene Mm.294007 Mm.468288
RefSeq NM_001291184 NM_011048 XM_006540706
OMIM
CCDS CCDS52267 CCDS71978
HPRD
IMGT
MGI ID MGI:102897
MGI Symbol Pcsk6
EMBL AC132595 AC148973 AC165968
GenPept
RNA Seq Atlas 18553

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca