InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ap1g1

Summary

InnateDB Protein

IDBP-191484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap1g1

Protein Name

adaptor protein complex AP-1, gamma 1 subunit

Synonyms

AA409002; Adtg; AU041323; AW551707; D8Ertd374e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034171

InnateDB Gene

IDBG-191480 (Ap1g1)

Protein Structure

UniProt Annotation

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0030117	membrane coat
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle
GO:0030665	clathrin-coated vesicle membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:101919

InterPro

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR008153 Clathrin adaptor, gamma-adaptin, appendage
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR016024 Armadillo-type fold
IPR017107 Adaptor protein complex AP-1, gamma subunit

PFAM

PF01602
PF02883

PRINTS

PIRSF

PIRSF037094

SMART

SM00809

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt