InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abca4

Summary

InnateDB Protein

IDBP-191487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abca4

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 4

Synonyms

Abc10; Abcr; AW050280; D430003I15Rik; RmP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013995

InnateDB Gene

IDBG-191485 (Abca4)

Protein Structure

UniProt Annotation

Function

In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor. {ECO:0000250}.

Disease Associations

Tissue Specificity

Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006649	phospholipid transfer to membrane
GO:0006810	transport
GO:0007601	visual perception
GO:0045332	phospholipid translocation
GO:0045494	photoreceptor cell maintenance
GO:0050896	response to stimulus
GO:0055085	transmembrane transport

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:109424

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005951 Rim ABC transporter
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35600