Version 5.4
Mus musculus Protein: Atg13
Summary
InnateDB Protein IDBP-191560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg13
Protein Name ATG13 autophagy related 13 homolog (S. cerevisiae)
Synonyms 1110053A20Rik; D2Ertd391e; Harbi1;
Species Mus musculus
Ensembl Protein ENSMUSP00000028678
InnateDB Gene IDBG-191556 (Atg13)
Protein Structure
UniProt Annotation
Function Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269PubMed:19258318}.
Subcellular Localization Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000045 autophagic vacuole assembly
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005829 cytosol
GO:0070969 ULK1-ATG13-FIP200 complex
Protein Structure and Domains
PDB ID MGI:1196429
InterPro IPR018731 Autophagy-related protein 13
PFAM PF10033
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YI1
PhosphoSite PhosphoSite-Q91YI1
TrEMBL
UniProt Splice Variant
Entrez Gene 51897
UniGene Mm.483747
RefSeq XP_006499951
MGI ID
MGI Symbol Atg13
OMIM
CCDS
HPRD
IMGT
EMBL AK122339 AK149672 AK171206 AK171440 AL714023 BC016669 BC023673 BC023712 BC033419 CH466519
GenPept AAH16669 AAH23673 AAH23712 AAH33419 BAC65621 BAE29016 BAE42312 BAE42453 CAM14512 CAM14513 EDL27574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca