InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Frs2

Summary

InnateDB Protein

IDBP-191604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Frs2

Protein Name

fibroblast growth factor receptor substrate 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020381

InnateDB Gene

IDBG-191602 (Frs2)

Protein Structure

UniProt Annotation

Function

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269PubMed:11353842, ECO:0000269PubMed:11390647, ECO:0000269PubMed:12181353, ECO:0000269PubMed:9182757, ECO:0000269PubMed:9632781}.

Subcellular Localization

Membrane {ECO:0000269PubMed:8780727}; Lipid-anchor {ECO:0000269PubMed:8780727}.

Disease Associations

Tissue Specificity

Ubiquitous. Expression is highest in brain, kidney, lung and testis. {ECO:0000269PubMed:9182757}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104	fibroblast growth factor receptor binding
GO:0005158	insulin receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001702	gastrulation with mouth forming second
GO:0001759	organ induction
GO:0002088	lens development in camera-type eye
GO:0003281	ventricular septum development
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007405	neuroblast proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008595	anterior/posterior axis specification, embryo
GO:0030900	forebrain development
GO:0042981	regulation of apoptotic process
GO:0046619	optic placode formation involved in camera-type eye formation
GO:0050678	regulation of epithelial cell proliferation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0070307	lens fiber cell development
GO:0070372	regulation of ERK1 and ERK2 cascade