InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tat

Summary

InnateDB Protein

IDBP-191635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tat

Protein Name

tyrosine aminotransferase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001720

InnateDB Gene

IDBG-191633 (Tat)

Protein Structure

UniProt Annotation

Function

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine. {ECO:0000269PubMed:21153519}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0008483	transaminase activity
GO:0016597	amino acid binding
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0006536	glutamate metabolic process
GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0006979	response to oxidative stress
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009072	aromatic amino acid family metabolic process
GO:0009074	aromatic amino acid family catabolic process
GO:0014070	response to organic cyclic compound
GO:0046689	response to mercury ion
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:98487

InterPro

IPR000192 Aminotransferase, class V/Cysteine desulfurase
IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase
IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR004839 Aminotransferase, class I/classII
IPR005957 Tyrosine aminotransferase
IPR005958 Tyrosine/nicotianamine aminotransferase
IPR011715 Tyrosine aminotransferase ubiquitination region
IPR015424 Pyridoxal phosphate-dependent transferase
IPR021178 Tyrosine transaminase

PFAM

PF00266
PF01041
PF01212
PF00155
PF07706

PRINTS

PIRSF

PIRSF000390
PIRSF000517

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8QZR1