InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tat

Summary

InnateDB Gene

IDBG-191633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tat

Gene Name

tyrosine aminotransferase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001670

Encoded Proteins

IDBP-191635

tyrosine aminotransferase

IDBP-539728

tyrosine aminotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:109990437-109999803

Strand

Forward strand

Band

Transcripts

ENSMUST00000001720	ENSMUSP00000001720
ENSMUST00000143741	ENSMUSP00000119061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0008483	transaminase activity
GO:0016597	amino acid binding
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0006536	glutamate metabolic process
GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0006979	response to oxidative stress
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009072	aromatic amino acid family metabolic process
GO:0009074	aromatic amino acid family catabolic process
GO:0014070	response to organic cyclic compound
GO:0046689	response to mercury ion
GO:0051384	response to glucocorticoid