InnateDB Protein
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IDBP-191638.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Yeats4
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Protein Name
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YEATS domain containing 4
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Synonyms
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4930573H17Rik; B230215M10Rik; GAS41; NuBI-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000020382
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InnateDB Gene
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IDBG-191636 (Yeats4)
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Protein Structure
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Function |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00376}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
30 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927224
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InterPro |
IPR005033
YEATS
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PFAM |
PF03366
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CR11
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PhosphoSite |
PhosphoSite-Q9CR11
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64050
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UniGene |
Mm.233529
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RefSeq |
NP_080846
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MGI ID |
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MGI Symbol |
Yeats4
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OMIM |
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CCDS |
CCDS24191
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HPRD |
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IMGT |
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EMBL |
AK002839
AK010522
AK012096
BC020043
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GenPept |
AAH20043
BAB22396
BAB27003
BAB28027
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