InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde5a

Summary

InnateDB Protein

IDBP-191820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde5a

Protein Name

phosphodiesterase 5A, cGMP-specific

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069011

InnateDB Gene

IDBG-191818 (Pde5a)

Protein Structure

UniProt Annotation

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0042130	negative regulation of T cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0046068	cGMP metabolic process
GO:0046069	cGMP catabolic process
GO:0055118	negative regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0060282	positive regulation of oocyte development

Cellular Component

Protein Structure and Domains

PDB ID

MGI:2651499

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like

PFAM

PF00233
PF01590
PF13185
PF13492

PRINTS

PR00387

PIRSF

SMART

SM00065
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt