InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde5a

Summary

InnateDB Gene

IDBG-191818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde5a

Gene Name

phosphodiesterase 5A, cGMP-specific

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053965

Encoded Proteins

IDBP-191820

phosphodiesterase 5A, cGMP-specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138735:
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5\'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:122729158-122859374

Strand

Forward strand

Band

Transcripts

ENSMUST00000066728

ENSMUSP00000069011

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0042130	negative regulation of T cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0046068	cGMP metabolic process
GO:0046069	cGMP catabolic process
GO:0055118	negative regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0060282	positive regulation of oocyte development