InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dgkz

Summary

InnateDB Protein

IDBP-191845.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgkz

Protein Name

diacylglycerol kinase zeta

Synonyms

E130307B02Rik; ENSMUSG00000075035; F730209L11Rik; mDGK[z];

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028667

InnateDB Gene

IDBG-191843 (Dgkz)

Protein Structure

UniProt Annotation

Function

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20023381}. Nucleus {ECO:0000269PubMed:20023381}. Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction
GO:0043086	negative regulation of catalytic activity
GO:0046580	negative regulation of Ras protein signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1278339

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002110 Ankyrin repeat
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020683 Ankyrin repeat-containing domain

PFAM