InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dgkz

Summary

InnateDB Gene

IDBG-191843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgkz

Gene Name

diacylglycerol kinase zeta

Synonyms

E130307B02Rik; ENSMUSG00000075035; F730209L11Rik; mDGK[z]

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040479

Encoded Proteins

IDBP-191845

diacylglycerol kinase zeta

IDBP-258410

diacylglycerol kinase zeta

IDBP-258414

diacylglycerol kinase zeta

IDBP-531655

diacylglycerol kinase zeta

IDBP-538147

diacylglycerol kinase zeta

IDBP-541707

diacylglycerol kinase zeta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149091:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:91932824-91975864

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028667	ENSMUSP00000028667
ENSMUST00000099709	ENSMUSP00000106937
ENSMUST00000111303	ENSMUSP00000106934
ENSMUST00000128152	ENSMUSP00000118684
ENSMUST00000142231	ENSMUSP00000114740
ENSMUST00000134103
ENSMUST00000138894
ENSMUST00000128902
ENSMUST00000148297
ENSMUST00000130023
ENSMUST00000124427
ENSMUST00000142090	ENSMUSP00000119615
ENSMUST00000126473

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001727	lipid kinase activity
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0035556	intracellular signal transduction
GO:0043086	negative regulation of catalytic activity
GO:0045930	negative regulation of mitotic cell cycle
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046834	lipid phosphorylation