InnateDB Protein
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IDBP-191956.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Clec9a
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Protein Name
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C-type lectin domain family 9, member a
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000056625
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InnateDB Gene
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IDBG-191954 (Clec9a)
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Protein Structure
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Function |
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269PubMed:18408006, ECO:0000269PubMed:18497879, ECO:0000269PubMed:19219027, ECO:0000269PubMed:22483802}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269PubMed:18408006}.
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Disease Associations |
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Tissue Specificity |
Isoform 4 expressed at high levels by CD8(+) dendritic cells (DCs), and at low levels by plasmacytoid DCs but not by other hematopoietic cells. {ECO:0000269PubMed:18408006, ECO:0000269PubMed:18497879}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2444608
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InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
PR00356
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BRU4
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PhosphoSite |
PhosphoSite-Q8BRU4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
232414
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UniGene |
Mm.420379
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RefSeq |
NP_001192292
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MGI ID |
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MGI Symbol |
Clec9a
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OMIM |
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CCDS |
CCDS57454
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HPRD |
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IMGT |
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EMBL |
AK036399
AK041288
BC087955
CH466523
EU339277
EU339278
EU339279
EU339280
EU339281
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GenPept |
AAH87955
ABZ04558
ABZ04559
ABZ04560
ABZ04561
ABZ04562
BAC29411
BAC30890
EDK99924
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