Version 5.4
Mus musculus Gene: Clec9a
Summary
InnateDB Gene IDBG-191954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec9a
Gene Name C-type lectin domain family 9, member a
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046080
Encoded Proteins
IDBP-191956
C-type lectin domain family 9, member a
IDBP-191958
C-type lectin domain family 9, member a
IDBP-627324
C-type lectin domain family 9, member a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22483800
Clec9a is restricted to dendritic cells, and specifically recognizes filamentous actin from necrotic cells. Clec9a ligand engagement is necessary for the priming of cytotoxic T cells against necrotic cell antigens. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 22483800
[Homo sapiens] CLEC9A is restricted to dendritic cells, and specifically recognizes filamentous actin from necrotic cells. CLEC9A ligand engagement is necessary for the priming of cytotoxic T cells against necrotic cell antigens.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197992:
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:129408862-129424764
Strand Forward strand
Band F3
Transcripts
ENSMUST00000058352 ENSMUSP00000056625
ENSMUST00000088075 ENSMUSP00000085394
ENSMUST00000164513 ENSMUSP00000128622
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197992
View Gene Order
ENSBTAG00000009537
Not yet available
Cross-References
SwissProt Q8BRU4
TrEMBL
UniProt Splice Variant
Entrez Gene 232414
UniGene Mm.391518 Mm.420379
RefSeq NM_001205363 NM_001205364 NM_172732
OMIM
CCDS CCDS39658 CCDS57454 CCDS57455
HPRD
IMGT
MGI ID MGI:2444608
MGI Symbol Clec9a
EMBL AK036399 AK041288 BC087955 CH466523 EU339277 EU339278 EU339279 EU339280 EU339281
GenPept AAH87955 ABZ04558 ABZ04559 ABZ04560 ABZ04561 ABZ04562 BAC29411 BAC30890 EDK99924
RNA Seq Atlas 232414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca