Version 5.4
Mus musculus Protein: Clec9a
Summary
InnateDB Protein IDBP-191958.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec9a
Protein Name C-type lectin domain family 9, member a
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000085394
InnateDB Gene IDBG-191954 (Clec9a)
Protein Structure
UniProt Annotation
Function Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269PubMed:18408006, ECO:0000269PubMed:18497879, ECO:0000269PubMed:19219027, ECO:0000269PubMed:22483802}.
Subcellular Localization Membrane {ECO:0000269PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269PubMed:18408006}.
Disease Associations
Tissue Specificity Isoform 4 expressed at high levels by CD8(+) dendritic cells (DCs), and at low levels by plasmacytoid DCs but not by other hematopoietic cells. {ECO:0000269PubMed:18408006, ECO:0000269PubMed:18497879}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2444608
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BRU4
PhosphoSite PhosphoSite-Q8BRU4
TrEMBL
UniProt Splice Variant
Entrez Gene 232414
UniGene Mm.420379
RefSeq NP_766320
MGI ID
MGI Symbol Clec9a
OMIM
CCDS CCDS39658
HPRD
IMGT
EMBL AK036399 AK041288 BC087955 CH466523 EU339277 EU339278 EU339279 EU339280 EU339281
GenPept AAH87955 ABZ04558 ABZ04559 ABZ04560 ABZ04561 ABZ04562 BAC29411 BAC30890 EDK99924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca