InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbbp5

Summary

InnateDB Protein

IDBP-191985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbbp5

Protein Name

retinoblastoma binding protein 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027700

InnateDB Gene

IDBG-191981 (Rbbp5)

Protein Structure

UniProt Annotation

Function

As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. {ECO:0000269PubMed:21335234}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0043627	response to estrogen
GO:0051568	histone H3-K4 methylation