InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rbbp5

Summary

InnateDB Gene

IDBG-191981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbbp5

Gene Name

retinoblastoma binding protein 5

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026439

Encoded Proteins

IDBP-191985

retinoblastoma binding protein 5

IDBP-790392

retinoblastoma binding protein 5

IDBP-790394

retinoblastoma binding protein 5

IDBP-790395

retinoblastoma binding protein 5

IDBP-790396

retinoblastoma binding protein 5

IDBP-790397

retinoblastoma binding protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117222:
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:132477365-132505659

Strand

Forward strand

Band

Transcripts

ENSMUST00000027700	ENSMUSP00000027700
ENSMUST00000190825	ENSMUSP00000139519
ENSMUST00000190997	ENSMUSP00000141003
ENSMUST00000187505	ENSMUSP00000141176
ENSMUST00000188575	ENSMUSP00000140344
ENSMUST00000189786	ENSMUSP00000140790
ENSMUST00000187834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0043627	response to estrogen
GO:0051568	histone H3-K4 methylation