InnateDB Protein
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IDBP-192018.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rnf7
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Protein Name
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ring finger protein 7
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Synonyms
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Rbx2; SAG;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000052856
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InnateDB Gene
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IDBG-192016 (Rnf7)
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Protein Structure
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Function |
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
13
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
50 [view]
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Molecular Function |
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Biological Process |
GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0008631
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intrinsic apoptotic signaling pathway in response to oxidative stress
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GO:0008637
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apoptotic mitochondrial changes
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GO:0016567
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protein ubiquitination
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GO:0043066
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negative regulation of apoptotic process
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GO:0045116
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protein neddylation
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Cellular Component |
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PDB ID |
MGI:1337096
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InterPro |
IPR001841
Zinc finger, RING-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WTZ1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19823
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UniGene |
Mm.447600
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RefSeq |
NP_035409
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MGI ID |
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MGI Symbol |
Rnf7
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OMIM |
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CCDS |
CCDS40730
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HPRD |
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IMGT |
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EMBL |
AF092877
AK003248
AK146030
BC011127
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GenPept |
AAD25961
AAH11127
BAB22666
BAE26843
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