Version 5.4
Mus musculus Gene: Rnf7
Summary
InnateDB Gene IDBG-192016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf7
Gene Name ring finger protein 7
Synonyms Rbx2; SAG
Species Mus musculus
Ensembl Gene ENSMUSG00000051234
Encoded Proteins
IDBP-192018
ring finger protein 7
IDBP-254885
ring finger protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114125:
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:96470937-96478675
Strand Reverse strand
Band E3.3
Transcripts
ENSMUST00000057500 ENSMUSP00000052856
ENSMUST00000071301 ENSMUSP00000108581
ENSMUST00000128955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019788 NEDD8 ligase activity
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0045116 protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114125
View Gene Order
ENSBTAG00000002185
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q9WTZ1
TrEMBL
UniProt Splice Variant
Entrez Gene 19823
UniGene Mm.447600
RefSeq NM_011279 XM_006510876
OMIM
CCDS CCDS40730
HPRD
IMGT
MGI ID MGI:1337096
MGI Symbol Rnf7
EMBL AF092877 AK003248 AK146030 BC011127
GenPept AAD25961 AAH11127 BAB22666 BAE26843
RNA Seq Atlas 102638621 102642416 102642790 19823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca