InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasa2

Summary

InnateDB Protein

IDBP-192047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasa2

Protein Name

RAS p21 protein activator 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034984

InnateDB Gene

IDBG-192045 (Rasa2)

Protein Structure

UniProt Annotation

Function

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) and phospholipids.

Subcellular Localization

Cell membrane {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:2149960

InterPro

IPR000008 C2 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00779
PF00169
PF00616

PRINTS

PR00360
PR00402

PIRSF

SMART

SM00239
SM00107
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt