InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rasa2

Summary

InnateDB Gene

IDBG-192045.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasa2

Gene Name

RAS p21 protein activator 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032413

Encoded Proteins

IDBP-192047

RAS p21 protein activator 2

IDBP-536986

RAS p21 protein activator 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155903:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member has a perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein; a compound suggested to function as a second messenger. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:96539300-96631617

Strand

Reverse strand

Band

E3.3

Transcripts

ENSMUST00000034984	ENSMUSP00000034984
ENSMUST00000128346	ENSMUSP00000115629
ENSMUST00000144376
ENSMUST00000188853
ENSMUST00000185435
ENSMUST00000190537

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000155903

View Gene Order

ENSBTAG00000015413

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

114713

UniGene

Mm.124502 Mm.393811 Mm.407852

RefSeq

NM_053268 XM_006510775 XM_006510776

OMIM

CCDS

CCDS23416

HPRD

IMGT

MGI ID

MGI:2149960

MGI Symbol

Rasa2

EMBL

GenPept

RNA Seq Atlas

114713