Version 5.4
Mus musculus Protein: Synpo2
Summary
InnateDB Protein IDBP-192075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Synpo2
Protein Name synaptopodin 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051570
InnateDB Gene IDBG-192073 (Synpo2)
Protein Structure
UniProt Annotation
Function Has an actin-binding and actin-bundling activity. {ECO:0000269PubMed:11673475}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11673475}. Cytoplasm {ECO:0000269PubMed:11673475}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle (By similarity). The nuclear export is XPO1-dependent. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, heart, colon, stomach, uterus and lung. Expression is restricted to muscle cell layers in colon, uterus and stomach. {ECO:0000269PubMed:11673475}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051371 muscle alpha-actinin binding
GO:0071889 14-3-3 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0030018 Z disc
Protein Structure and Domains
PDB ID MGI:2153070
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YE8
PhosphoSite PhosphoSite-Q91YE8
TrEMBL
UniProt Splice Variant
Entrez Gene 118449
UniGene Mm.483280
RefSeq XP_006500986
MGI ID
MGI Symbol Synpo2
OMIM
CCDS
HPRD
IMGT
EMBL AC121315 AC121540 AJ306625 AK079194
GenPept BAC37575 CAC67798

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca