InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cntn2

Summary

InnateDB Protein

IDBP-192097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cntn2

Protein Name

contactin 2

Synonyms

D130012K04Rik; TAG-1; Tax;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083707

InnateDB Gene

IDBG-192095 (Cntn2)

Protein Structure

UniProt Annotation

Function

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0043621	protein self-association

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007612	learning
GO:0007628	adult walking behavior
GO:0010769	regulation of cell morphogenesis involved in differentiation
GO:0010954	positive regulation of protein processing
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0022010	central nervous system myelination
GO:0031133	regulation of axon diameter
GO:0031175	neuron projection development
GO:0031623	receptor internalization
GO:0034613	cellular protein localization
GO:0045163	clustering of voltage-gated potassium channels
GO:0045665	negative regulation of neuron differentiation
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048710	regulation of astrocyte differentiation
GO:0060168	positive regulation of adenosine receptor signaling pathway
GO:0071205	protein localization to juxtaparanode region of axon
GO:0071206	establishment of protein localization to juxtaparanode region of axon
GO:0097090	presynaptic membrane organization

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0009986	cell surface
GO:0030424	axon
GO:0031225	anchored component of membrane
GO:0033268	node of Ranvier
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0044224	juxtaparanode region of axon

Protein Structure and Domains

PDB ID

MGI:104518

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61330