InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klrk1

Summary

InnateDB Protein

IDBP-192144.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klrk1

Protein Name

killer cell lectin-like receptor subfamily K, member 1

Synonyms

D6H12S2489E; NKG2-D; Nkg2d;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032252

InnateDB Gene

IDBG-192142 (Klrk1)

Protein Structure

UniProt Annotation

Function

Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. {ECO:0000269PubMed:10894171, ECO:0000269PubMed:11248803, ECO:0000269PubMed:11557981, ECO:0000269PubMed:11567106, ECO:0000269PubMed:12150888, ECO:0000269PubMed:12370332, ECO:0000269PubMed:12426564, ECO:0000269PubMed:12426565, ECO:0000269PubMed:15189740, ECO:0000269PubMed:16086018, ECO:0000269PubMed:18394936, ECO:0000269PubMed:19631564, ECO:0000269PubMed:21898152, ECO:0000269PubMed:23298206}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12426565, ECO:0000269PubMed:15294961}; Single-pass type II membrane protein {ECO:0000269PubMed:12426565, ECO:0000269PubMed:15294961}. Note=Colocalized with HCST and TYROBP on the cell surface.

Disease Associations

Note=Involved in autoreactive CD8(+) T-cell-mediated development of autoimmune diabetes. {ECO:0000269PubMed:15189740}.

Tissue Specificity

Expressed in natural killer (NK) cells, activated CD8(+) alpha-beta and gamma-delta T-cells and natural killer T (NKT) cells (at protein level). May be expressed on dendritic cell (DC). Isoform 1 is strongly expressed in natural killer (NK) cells. Isoform 2 is weakly expressed in natural killer (NK) cells. Isoform 1 and isoform 2 are expressed in stimulated, but not in unstimulated, CD8(+) T-cells and macrophages. {ECO:0000269PubMed:11248803, ECO:0000269PubMed:11567106, ECO:0000269PubMed:12150888, ECO:0000269PubMed:15048723}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0030246	carbohydrate binding
GO:0032394	MHC class Ib receptor activity
GO:0042288	MHC class I protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002223	stimulatory C-type lectin receptor signaling pathway
GO:0030101	natural killer cell activation
GO:0030154	cell differentiation
GO:0032729	positive regulation of interferon-gamma production
GO:0045087	innate immune response
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050830	defense response to Gram-positive bacterium
GO:0071222	cellular response to lipopolysaccharide